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Crelux

Kinase of the month

Kinase: Lyn kinase, FLJ26625, JTK8
Gene Links: iHOP
Biological significance: Key enzyme in the regulation of cell activation via Syk, PLCγ2 and PI3K


Competition:

Lyn kinase inhibitors Preclinical Melior Discovery WO2007024863 
Lyn kinase inhibitors Preclinical Childrens Medical Center/Yissum (Keryx?) WO2002047710 
Lyn knockout mice Preclinical Japan Science and Technology Corp (JST) WO0215680
Lyn knockout mice Preclinical Ludwig Inst US5859314, WO9714791 
INNO-406, Bcr-Abl/Lyn inhibitor Phase I, CML, ALL Nippon Shinyaku/Innovive  
Lyn B kinase inhibitor Preclinical, Cancer Onconova  
Lyn kinase peptide   US Gov US6084063
 
 
Kinase patents Kinase Links

(For the week ending August 8, 2008)

US20080188643 Flk1 Amgen
US7407946 Aurora AstraZeneca
US20080188502 GSK3 AstraZeneca
US20080188503 GSK3 AstraZeneca
WO2008/094574 ALK5, ALK4 Biogen Idec
WO2008/094556 ALK5, ALK4 Biogen Idec
WO2008/094602 Aurora, PLK,CDK Biogen Idec
WO2008/094575 Aurora, PLK,CDK Biogen Idec
US20080188511 mTOR Biotica
WO2008/092831 PI3K Boehringer Ingelheim
US20080188457 GSK3 Braincells
WO2008/094254 Stat3 City of Hope
US7407939 Kinase Curegenics
WO2008/092199 JAK1, JAK2,JAK3 Cytopia
US20080187978 p38 Deciphera
US20080188482 Akt1, Akt2 Exelixis
US20080187534 VEGF Genentech
WO2008/094969 PDGFR, VEGFR-2 Genentech
US20080187575 Multikinase GPC
US7408040 PDGF-D Helsinki Univ/Ludwig Inst
US7407989 Kinase Hosp Sick Children
US20080188500 Abl, JAK Incyte
US20080188524 CDK Ingenium
WO2008/094937 PKC epsilon Joslin Diabetes Center
US20080187529 VEGF Kyowa Hakko
WO2008/095015 VEGFR MA Gen Hosp
US20080188531 PI3K Merck Serono
WO2008/094208 p38 MAPK, JNK, ERK, CK1delta Northwestern Univ
US20080188451 Multikinase Novartis
US20080188483 Multikinase Novartis
WO2008/094737 Flt3 Novartis/Scripps
WO2008/093827 EphA Osaka Industrial Promotion Org
US7407971 CDK Pfizer
US20080188514 Kinase Plexxikon
US20080188454 Axl Rigel
US20080188455 Axl Rigel
US20080188474 Axl Rigel
US7407981 Kinase Sanofi-Aventis
WO2008/093674 Kinase Santen
WO2008/094484 Multikinase Schering
US20080188423 PI3K Semaphore
US7407958 ALK4, ALK5 SK chemicals
US20080188453 MAPK, ERK Takeda
US20080188654 p44/42 MAP Theracos
US20080188461 mTOR Univ Michigan
WO2008/094181 mTOR Univ Michigan
US20080187992 STAT Univ S Florida
WO2008/093246 VEGF Vegenics
US7407962 ERK2, GSK3, PKA, CDK2 Vertex
WO2008/094992 Kinase Vertex
Kinase.com
Protein Kinase Resource
Protein Kinase Research Consortium
The Human Kinome
Receptor Tyrosine Kinase (RTK) Networks Consortium 

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  Upcoming Kinase Meetings

The Second q-bio Conference on Cellular Information Processing
August 6-9, 2008, Santa Fe, NM
Polo-like Kinases: From the Fly to the Clinic 20 Years Onwards
September 24 - 27, 2008, Porto, Portugal
Kinase Inhibitors
Oct 21-22 2008, Boston, MA
Targeting the PI3-Kinase Pathway in Cancer Prevention
Nov 11-14 2008, Cambridge, MA
Signaling Upstream of mTOR
November 3 - 5, 2008, Madrid, Spain

Companies Working on Kinases, kinasecentral

 

Click here for a list of companies working on Kinase inhibitors

 
   

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